Study of Hypolipidemic Mechanisms and Efficacy of the Compound Prescription of FTZ Based on the HMG-CoA Reductase 复方贞术调脂方基于HMG-CoA还原酶的降脂作用机制及药效物质基础研究
The establishment of virtual screening models for the discovery of HMG-CoA reductase inhibitors HMG-CoA还原酶抑制剂的虚拟筛选模型的建立
The association of HMG-CoA reductase gene single nucleotide polymorphisms with coronary heart disease HMG-CoA还原酶基因单核苷酸多态性与冠心病的关系
Aim To seek and design new kinds of HMG-CoA reductase inhibitors. 目的寻找和设计新的HMG-CoA还原酶抑制剂。
Objective To investigate the role of HMG-CoA reductase inhibitor, fluvastatin in the earlier cardiomyopathy of SD diabetic rats. 目的探讨氟伐他汀对糖尿病大鼠早期心肌病变的作用。
The mechanism of effect of Acanthopanax senticosus on liver microsomal HMG-CoA reductase and 7 α-hydroxylase was proved to be reversible phosphorylation and dephosphorylation via corresponding kinase and protein phosphatase. 刺五加水煎液对肝微粒体羟甲基戊二酰辅酶A还原酶和胆固醇7α-羟化酶活力调节作用是通过可逆的磷酸化及脱磷酸化作用而实现的。
Atorvastatin is a new generation of HMG-CoA reductase inhibitors ( blood lipid lowering agent of statins class). 阿托伐他汀钙是新一代羟甲戊二酰辅酶A(HMG-CoA)还原酶抑制剂(他汀类降血脂药)。
AIM: To evaluate the effect of atorvastatin on HMG-CoA reductase ( HMGR) expression level in spontaneously hypertensive rats ( SHR). 目的:评价阿托伐他汀对自发性高血压大鼠(SHR)HMG-CoA还原酶表达的影响。
Structure and Regulation of HMG-CoA Reductase HMG-CoA还原酶的结构和调节
Objective: To investigate the protective effects of angiotension II receptor antagonist Losartan and HMG-CoA reductase inhibitor Simvastatin on the kidneys of diabetic rats, and study their possible mechanisms. 目的:探讨血管紧张素Ⅱ受体拮抗剂氯沙坦和羟甲基戊二酰辅酶A(HMGCoA)还原酶抑制剂辛伐他汀对糖尿病大鼠肾脏病变的保护作用及其可能机制。
Recent progress in understanding the molecular and cellular pathophysiology of Alzheimer's disease has suggested possible pharmacological interventions, such as treatment with secretase inhibitors, transition metal chelators, HMG-CoA reductase inhibitors and amyloid-β immunization. 随着对AD分子和细胞病理生理的进一步了解,又发展了医一些新的治疗方法,如分泌酶抑制剂、过渡金属元素螯合剂、HMGCoA还原酶抑制剂和β淀粉样蛋白疫苗等。
3D-QSAR study of statin inhibitors of HMG-CoA reductase HMG-CoA还原酶抑制剂的3D-QSAR研究
Expression of p38 MAPK Signal Transduction Pathway and Effect of HMG-CoA Reductase Inhibitor in Diabetic Nephropathy p38MAPK信号转导通路在糖尿病肾病发病中的作用及HMG-CoA还原酶抑制剂的影响
A comparison of inhibition of pravastatin on HMG-CoA reductase with enalapril and verapamil in SDR and SHR liver 普伐他汀、依那普利和维拉帕米对SDR和SHR肝脏HMG-CoA还原酶抑制作用的比较
Study on lipemia modulator. Isolation and identification of HMG-CoA reductase inhibitor m-8614a and hm-2688b 血脂调节剂的研究&Ⅱ.HMG-CoA还原酶抑制剂M-8614A及MH-2688B的分离和鉴别
Lovastatin is a potent cholesterol-lowering drug. This fungal secondary metabolite and its derivatives act as competitive inhibitors of HMG-CoA reductase, the rate limiting enzyme in the biosynthesis of cholesterol. 洛伐他汀是一种有效的降胆固醇药物,这种真菌次生代谢产物及其衍生物是胆固醇生物合成限速酶&HMGCoA还原酶的竞争性抑制剂。
Conclusion: Sodium propionate may decrease the activity of hepatic HMG-CoA reductase and suppress the synthesis of cholesterol. 结论:丙酸钠可以抑制肝脏HMG-CoA还原酶的活性,有效地减少肝脏胆固醇的合成。
Cloning and Sequence Analysis of HMG-CoA Reductase Gene in Porcine Liver 猪肝脏HMG-CoA还原酶基因的部分序列克隆及分析
Effects of HMG-CoA Reductase Inhibitors on Proliferation of Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats HMG-CoA还原酶抑制剂对自发性高血压大鼠血管平滑肌细胞增殖的作用
Effects of HMG-CoA Reductase Inhibitor on Proliferation and Differentiation of MCF-7 Human Breast Cancer Cells& Its Molecular Mechanisms HMG-CoA还原酶抑制剂对MCF-7乳腺癌细胞增殖抑制和诱导分化作用及其机制的研究
Role of intracellular calcium in proliferation inhibition of MCF-7 cells induced by HMG-CoA reductase inhibitor 细胞内Ca~(2+)在HMG-CoA还原酶抑制剂抑制MCF-7细胞增殖中的作用
AIM To investigate the effect of OX-LDL and HMG-CoA reductase inhibitors simvastatin on PKC activity and cytosolic free Ca2+ in cultured human monocytes. 目的探讨OX-LDL及HMG-CoA还原酶抑制剂辛伐他汀对人单核细胞(Mo)表达蛋白激酶C(PKC)活性和胞浆内游离钙(〔Ca2+〕i)浓度的影响。
Effect of HMG-COA Reductase Gene Polymorphism on the Rate of Reaching Lipid Target in Hyperlipidemic CHD Subjects Using Atorvastatin HMG-COA还原酶基因多态性及阿托伐他汀对冠心病高脂血症患者降脂达标率的研究
Polymorphisms in the HMG-CoA Reductase Gene and Their Association with Coronary Heart Disease HMG-GoA还原酶基因多态性与冠心病的相关性研究
Effects of HMG-CoA Reductase Inhibitors on Connexin Expression between Proliferating Smooth Muscle Cells in the Rabbit Aterial Wall HMG-CoA还原酶抑制剂对家兔血管平滑肌增殖中连接蛋白的影响
Effects of HMG-CoA Reductase Inhibitor on the Expression of Low Density Lipoprotein Receptor in Liver of Nephrotic Rats HMG-CoA还原酶抑制剂对肾病综合征大鼠肝脏低密度脂蛋白受体表达的影响
Thus, the relationship between HMG-CoA reductase inhibitors and the Ras/ Raf/ ERK/ CREB signal pathway are worthy of further exploration. 由此,HMG-CoA还原酶抑制剂与Ras/Raf/ERK/CREB信号通路的关系值得深入探讨。
Atorvastatin inhibited proliferation of cells of patients with acute leukemia. It is possible for HMG-CoA reductase inhibitor to serve as adjunctive therapy for leukemia. 阿托伐他汀具有抑制急性白血病细胞增殖的作用,HMG-CoA还原酶抑制剂具有辅助治疗白血病的可能性。